Which Drugs Affect Blood Glucose Levels? - 443 OTC & Prescription Meds (2023)

What drugs affect glucose levels? Many can, including steroids, anxiety and depression medications, statins, beta-blockers, some acne & asthma medications.

Knowing which drugs affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way.

443 Drugs that can Affect Blood Glucose Levels is also available as a downloadable PDF.

Last Revised: 04/5/2020

Table of Contents:

Drugs that May Cause Hyperglycemia

Drugs that May Cause Hypoglycemia

Drugs that May Cause Hyper- or Hypoglycemia

Drugs that Mask Hypoglycemia

DiabetesinControl 2020©

Drugs That May Cause Hyperglycemia (High Blood Sugar)

Abacavir (Ziagen®)

Abacavir + lamivudine, zidovudine (Trizivir®)

Abacavir + dolutegravir + lamivudine (Triumeq®)

Abiraterone (Zytiga®)

Acetazolamide (Diamox®)

Acitretin (Soriatane®)

Albuterol (Ventolin®, Proventil®)

Albuterol + ipratropium (Combivent®)

Alectinib (Alecensa®)

Aliskiren + amlodipine + hydrochlorothiazide (Amturnide®)

Aliskiren + amlodipine (Tekamlo®)Ammonium chloride

Amphotericin B (Amphocin®, Fungizone®)

Amphotericin B lipid formulations IV (Abelcet®)

Amprenavir (Agenerase®)

Anidulafungin (Eraxis®)

Aripiprazole (Abilify®)

Arsenic trioxide (Trisenox®)

Asenapine (Saphris)

Asparaginase (Elspar®, Erwinaze®)

Atazanavir (Reyataz ®)

Atazanavir + cobistat (Evotaz®)

Atenolol + chlorthalidone (Tenoretic®)

Atorvastatin (Lipitor®)

Atovaquone (Mepron®)

Baclofen (Lioresal®)

Belatacept (Nulojix®)Benazepril + hydrochlorothiazide (Lotension®)

Betamethasone topical (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Betamethasone +clotrimazole (Lotrisone® topical)

Betaxolol Betoptic® eyedrops, (Kerlone® oral)

Bexarotene (Targretin®)

Bicalutamide (Casodex®)

Bisoprolol + hydrochlorothiazide (Ziac®)

Brentuximab vedotin (Adcetris®)

Budesonide (Uceris®)

Bumetanide (Bumex®)

Caffeine (Caffeine in moderation may be beneficial in diabetes, but in large amounts can raise blood sugar.)

Calcipotriene + betamethasone (Enstillar®)

Candesartan + hydrochlorothiazide (Atacand HCT®)Captopril + hydrochlorothiazide (Capozide®)

Carfilzomib (Kyprolis®)

Cariprazine (Vraylar)

Carteolol (Cartrol® oral, Occupress® eyedrops)

Carvedilol (Coreg®)

Caspofungin (Cancidas)

Ceftaroline (Teflaro®)

Ceftozolane + tazobactam (Zerbaxa)

Ceritinib (Zykadia)

Chlorothiazide (Diuril®)

Chlorthalidone (Chlorthalidone Tablets®, Clorpres®, Tenoretic®, Thalitone®)

Choline salicylate (Numerous tradenames of aspirin formulations; check the label)

Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®)

Ciprofloxacin (Cipro)

Clobetasol (Clobevate®, Cormax®, Cormax® Scalp Application, Embeline® E, Olux®, Temovate®, Temovate® E, Temovate® Scalp Application)

Clozapine (Clozaril®, FazaClo®)

Conjugated estrogens (Estrace®, Estring®, Femring®, Premarin®, Vagifem®, Cenestin®, Enjuvia®, Estrace®, Femtrace®, Gynodiol®, Menest®, Ogen®)

Conjugated estrogens + bazedoxifene (Duavee®)

Conjugated estrogens + medroxyprogesterone (Premphase®, Prempro®)

Corticosteroids (Numerous tradenames; check the label)

Corticotropin

Cortisone (Numerous tradenames; check the label)

Crizotinib (Xalkori)

Cyclosporine (Sandimmune®, Neoral®, Gengraf®)

Dabrafenib (Tafiniar®)

Daclizumab (Zenapax®)

Darunavir (Prezista)

Darunavir + cobistat (Prezcobix®)

Decitabine (Dacogen®)

Desonide (DesOwen®, Tridesilon®)

Desoximetasone (Topicort®)

Dexamethasone (Adrenocot®, Dalalone®, Decadron®, Decaject®, Dekasol®, Dexacort®, Dexasone®, Dexim®, Dexone®, Hexadrol®, Medidex®, Primethasone®, Solurex®, Dexamethasone Intensol®)

Dextromethorphan + promethazine (Phenergan® with Dextromethorphan, Phen- TussDM®)

Diazoxide (Proglycem®)

Dinutuximab (Unituxin®)

Dolutegravir (Tivicay®)

Enalapril + hydrochlorothiazide (Vaseretic®)Encainide (Enkaid®)

Ephedrine and Guaifenesin (Primatene ® tablets, otc – this medication includes ephedrine and guaifenesin. Guaifenesin is not responsible for hyperglycemia )

Epinephrine (EpiPen ®, EpiPen® Jr, Primatene® Mist, otc)

Esterified estrogens, estrone, estropipate

Esterified estrogens + methyltestosterone (Estratest®)

Estradiol, ethinyl estradiol (Alora®, Climara®, Congest®, Delestrogen®, Depo-Estradiol®, Depogen®, Estinyl®, Estrace®, Estraderm®, Estragyn 5®, Estragyn LA 5®, Estrasorb®, EstroGel®, Estro-L.A.®, Gynodiol®, Kestrone-

5®, Neo-Estrone®, Menest®, Menostar®, Ogen .625®, Ogen®, Ortho-Est®, Premarin®, Valergen®, Vivelle®, Vivelle-Dot®)

Estradiol + norethindrone (Activella®)

Estradiol + norgestimate (Prefest®)

Estramustine (Emcyt®)

Ethacrynic acid (Edecrin®, Sodium Edecrin®)

Etravirine (Intelence)

Everolimus (Afinitor®, Zortress®)

Everolimus (Zortress®)

Ezetimibe, Atorvastatin (Liptruzet®)

Fidaxomicin (Dificid®)

Fluconazole (Diflucan)

Fluticasone (Arnuity Ellipta®)

Fluticasone + vilanterol (Breo Elipta®)

Fluoxetine (Prozac®, Sarafem®)

Flurandrenolide (Cordran®, Cordran® SP, Cordran® Tape)

Fluvastatin (Lescol, Lescol XR)

Formoterol (Foradil® Aerolizer® Inhaler)

Fosamprenavir (Lexiva ®)

Fosinopril + hydrochlorothiazide (Monopril HCT®)

Furosemide (Lasix®)

Gabapentin (Gralise®, Horizant®)

Gemtuzumab ozogamicin (Mylotarg®)

Glucosamine (Possible increase in insulin resistance; more likely with intravenous use)

Glycopyrrolate (Cuvposa®)

Hydrochlorothiazide (Aldactazide®, Aldoril®, Capozide®, Dyazide®, HydroDIURIL®, Inderide®, Lopressor® HCT, Maxzide®, Microzide®, Moduretic®, Timolide®, Vaseretic®)

Hydrochlorothiazide + irbesartan (Avalide®)

Hydrochlorothiazide + lisinopril (Prinzide®, Zestoretic®)

Hydrochlorothiazide + losartan (Hyzaar®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Hydrochlorothiazide + moexipril (Uniretic®)

Hydrochlorothiazide + quinapril (Accuretic®, Quinaretic®)

Hydrochlorothiazide + telmisartan (Micardis HCT®)

Hydrochlorothiazide + valsartan (Diovan HCT®)

Hydrocortisone (Numerous trade names of topical hydrocortisone formulations; check the label)

Iloperidone (Fanapt)

Indacaterol (Arcapta®)

Indapamide (Lozol®)

Indinavir (Crixivan®)

Interferon alfa-2a (Roferon-A®)

Interferon alfa-2b (Intron-A®)

Interferon alfa-2b + ribavirin (Rebetron®)

Interferon alfa-n1 (Alferon-N®)

Irinotecan (Camptosar®)

Isavuconazonium sulfate (Cresemba)

Isoniazid (Laniazid®, Nydrazid®)

Isotretinoin (Accutane®)

Itraconazole (Sporanox, Sporanox PuslePak, Tolsura)

Ketoconazole (Nizoral)

Liothyronine (Cytomel®)

Lamivudine (Epivir®, Epivir-HBV®)

Levalbuterol (Xoponex®, Xopenex HFA®)

Levonorgestrel (Plan B®, Norplant System®)

Levothyroxine (Synthroid®, Levoxyl®)

Lisinopril + Hydrochlorothiazide

Lopinavir + ritonavir (Kaletra®)

Lovastatin (Altoprev, Mevacor)

Lucinactant (Surfaxin®)

Lurasidone (Latuda®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Medroxyprogesterone (Provera®, Depo-Provera®)

Megestrol (Megace®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Methylprednisolone (A-methaPred®, ADD-Vantage®, Depo-Medrol®, Medrol®,
Medrol® Dosepak, Meprolone® Unipak, Solu-Medrol®)

Metolazone (Zaroxolyn®, Mykrox®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Micafungin (Mycamine)

Modafinil (Provigil®)

Momentasone furoate + formoterol fumarate dihydrate (Dulera®)

Moxifloxacin (Avelox®, Avelox® I.V.)

Mycophenolate (CellCept®)

Nadolol (Corgard®)

Nelfinavir (Viracept®)

Netupitant + palonosetron (Akynzo®)

Niacin, niacinamide (Niacor®, Niaspan®, Nicolar®, Nicotinex®, Slo-Niacin®)

Nilotinib (Tasigna®)

Nilutamide (Nilandron®)

Nitric oxide (INOmax®)

Nivolumab (Opdivo®)

Norethindrone (Aygestin®, Nor-QD®, Micronor®)

Norgestrel (Orvette®)

Nystatin (Mycostatin®, Nystat-Rx®, Nystop®, Pedi-Dri®)

Nystatin + triamcinolone (Dermacomb®, Myco II®, Mycobiotic II®, Mycogen II®,
Mycolog II®, Myco-Triacet II®, Mykacet®, Mykacet II®, Mytrex®, Tristatin II®)

Octreotide (Sandostatin®, Sandostatin LAR®)

Olanzapine (Zyprexa®)

Olaparib (Lynparza®)

Olmesartan + amlodipine + hydrochlorothiazide (Tribenzor®)

Oxybutynin (Anturol®)

Oxycodone (Oxecta®)

Paliperidone (Invega, Invega Sustenna, Invega Trinza)

Panobinostat (Farydak®)

Pantoprazole (Protonix®, Protonix® I.V.)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Pegaspargase (Oncaspar®)

Peginterferon alfa-2b (PEG-Intron®, Sylatron®)

Pembrolizumab (Keytrenda®)

Pentamidine (Pentam 300®)

Peramivir (Rapivab®)

Perindopril + amlodipine (Prestalia®)

Phenylephrine* (Sudafed PE®, and others)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Pitavastatin (Livalo, Zypitamag)

Pomalidomide (Pomalyst®)

Posaconazole (Noxafil)

Pravastatin (Pravachol)

Prednisolone (AK-Pred®, Blephamide®, Blephamide®, Liquifilm®, Econopred® Plus, Inflamase® Forte, Inflamase® Mild, Poly-Pred® Liquifilm®, Pred Forte®, Pred Mild®, Pred-G®, Pred-G® Liquifilm®, Delta Cortef®, Pediapred®, Prelone®)

Prednisone (Prednisone Intensol®, Sterapred®, Sterapred® DS, Rayos DR®)

Progesterone (Prometrium®)

Pseudoephedrine* (Claritin D®, Sudafed®, and others)

Quetiapine (Seroquel®)

Risperidone (Risperdal®, Risperdal® M-TAB®)

* many other OTC and prescription medications contain pseudoephedrine and phenylephrine.

Ritodrine (Yutopar®)

Ritonavir (Norvir®)

Rituximab (Rituxan®)

Rosuvastatin (Crestor)

Salmeterol (Serevent®, Serevent® Diskus®)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Saquinavir (Invirase®)

Simvastatin (Zocor)

Simvastatin + ezetimibe (Vytorin)

Sodium oxybate (Xyrem®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin artridges®, Norditropin NordiFlex®, Nutropin®, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Sonidegib (Odomzo®)

Sotalol (Betapace®, Betapace AF®, Sorine®)

Stavudine (Zerit)

Streptozocin (Zanosar®)

Tacrolimus (Prograf®, Protopic®)

Temsirolimus (Torisel®)

Tesamorelin (Egrifta®)

Thyroid (Armour Thyroid®, Naturethroid®)

Tiotropium + Olodaterol (Stiolto Respimat®)

Tipranavir (Aptivus®)

Tolvaptan (Samsca®)

Torsemide (Demadex®, Demadex Oral®)

Trametinib (Mekinist®)

Triamcinolone (Aristocort®, Aristospan®, Asthmacort®, Flutex®, Kenalog®, Tac®, Triacet®)

Umeclidium + vilanterol (Anoro Ellipta®)

Ursodeoxycholic acid, ursodiol (Actigall®, Urso®)

Valproic acid, divalproex sodium (Depacon®, Depakene®, Depakene® Syrup, Depakote®, Depakote® ER, Depakote® Sprinkle)

Vitamin C (Ascorbic acid, Ascorbate)

Vitamin E (Tocopherol, Tocotrienol)

Voriconazole (Vfend)

Zidovudine (Retrovir)

Ziprasidone (Geodone®)

Zolpidem (Intermezzo®)

Drugs That May Cause Hypoglycemia (Low Blood Sugar)

Acebutolol (Sectral®)

Acetohexamide (Dymelor®)

Albiglutide (Tanzeum®)

Alcohol

Albiglutide (Tanzeum)

Aloe – Oral Herbal Supplement, especially if taken with other agents such as glyburide, glipizide, nateglinide, repaglinide, glimepiride, or insulin.

Alogliptin (Nesina®)

Alogliptin/pioglitazone (Oseni®)

Alogliptin/metformin (Kazano®)

Amphotericin B (Ambisome®, Amphocin®, Fungizone Intravenous® Amphotec®, Abelcet®)

Amphotericin B lipid formulations (Abelcet®, AmBisome®)

Aripiprazole (Aristada®)Asian Ginseng (Ginseng; Panax ginseng)

Aspirin (Numerous tradenames; check the label)

Aspirin + dipyridamole (Aggrenox®)

Atenolol (Tenormin®, Tenoretic® containing atenolol & chlorthalidone)

Benazepril (Lotensin)

Betaxolol (Betoptic®, Betoptic S® eyedrops, Kerlone® oral)

Bisoprolol (Zebeta®)

Bisoprolol + hydrochlorothiazide (Ziac®)

Brexpiprazole (Rexulti®)

Bromocriptine (Cycloset®)

Canagliflozin (Invokana®)

Canagliflozin + metformin (Invokamet®)

Chloramphenicol (Chloromycetin®)

Chlorpropamide (Diabinese®)

Choline salicylate (Acuprin 81®, Amigesic®, Anacin Caplets®, Anacin Maximum Strength®, Anacin Tablets®, Anaflex 750® Arthritis Pain, Ascriptin® Arthritis Pain)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Choline salicylate + magnesium salicylate C (MT®, Tricosal®, Trilisate®)

Chloramphenicol (Chloromycetin, Econochlor, Ocu-Chlor)Chloroquine (Aralen)

Chromium (Various tradenames; check the label)

Ciprofloxacin (Cipro)

Clarithromycin B (Biaxin® Filmtab®, Biaxin® Granules, Biaxin® XL, Filmtab,
Biaxin® XL Pac, Prevpac®)

Clofibrate (Atromid-S)

Colesevelam (Welchol)

Dalbavancin (Dalvance®)

Dapagliflozin (Farxiga®)

Dapagliflozin + Metformin (Xigduo XR®)

Diazoxide (Proglycem®)

Dicumarol (Coumadin®, Miradon®)

Diltiazem (Cardizem®, Tiazac®)

Disopyramide (Norpace®, Norpace® CR)

Dorzolamide + timolol (Cosopt®)

Doxepin (Silenor®)

Dulaglutide (Trulicity®)

Empagliflozin (Jardiance®)

Empagliflozin/linagliptin (Glyxambi®)

Empagliflozin + metformin (Synjardy®)

Enalapril (Vasotec)

Ertugliflozin ( Steglatro)

Ertugliflozin + metformin (Segluromet)

Ertugliflozin + metformin + linagliptin (Trijardy)

Esmolol (Brevibloc)

Exenatide (Byetta®, Bydureon®)

Fluoxetine (Prozac®, Sarafem®)

Fosphenytoin (Cerebyx®, Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Mesantoin®, Peganone®, Phenytek®)

Gatifloxacin (Gatiflo, Tequin, Zymar)

Glimepiride (Amaryl®)

Glimepiride and Rosiglitazone (Avandaryl®)

Glimepiride + pioglitazone (Duetact)

Glipizide (Glucotrol®, Glucotrol XL®)

Glipizide and Metformin (Metaglip®)

Glucagon (GlucaGen®)

Glyburide (Diabeta®, Glynase®, Micronase®, Glycron®)

Glyburide + metformin (Glucovance®)

Horse chestnut (Aesculus hippocastanum)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Hydroxychloroquine (Plaquenil)

Indomethacin (Indocin)

Insulin (Lantus®, Levemir®, NPH®, Humulin®, Novolin®, Apidra®, Novolog®, Humalog®, Tresiba®, Afrezza®- inhaled, Abasaglar®, Ryzodeg®, Xultophy®- not FDA approved, Toujeo®, Locemia®- not FDA approved, V-go®)

Interferon beta-1b (Betaseron®)

Isavuconazonium (Cresemba®)

ITCA 650®- Not FDA approved

Lenvatinib (Lenvima®)

Levobunolol (AKBeta, Betagan, Vistagan)

Levofloxacin (Levaquin®, Levaquin® in Dextrose Injection Premix, Quixin®)

Linagliptin (Tradjenta®)

Linagliptin + empagliflozin (Glyxambi)

Linagliptin + metformin (Jentadueto®, Jentadueto XR)

Liraglutide (Victoza®, Saxenda®)

Liraglutide + insulin degludec (Xultophy)

Lisinopril (Prinivil, Zestril, Qbrelis)

Lithium (Eskalith, Lithobid)

Lixisenatide (Lyxumia®)- currently approved in Europe

Lixisenatide/ insulin Glargine (Soliqua®)-

Lorcaserin (Belviq®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, Riomet®)

Metipranolol (Optipranolol)

metreleptin (Myalept®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Metreleptin (Myalept®)

Mifepristone (Korlym®)

Morphine (Kadian®, MS Contin®, MSIR®, Roxanol®)

Moxifloxacin (Avelox)

Nadolol (Corgard®)

Nateglinide (Starlix®)

Nebivolol (Bystolic)

Nifedipine (Adalat CC®, Procardia®, Afeditab ® CR)

Nivolumab (Opdivo®)

Norfloxacin (Noroxin)

Octreotide (Sandostatin®, Sandostatin LAR® Depot)

Ofloxacin (Oxuflox)

Oritavancin (Orbactiv®)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Paliperidone (Invega®)

Penicillamine (Cuprimine®, Depen®)

Pentamidine (Nebupent®, Pentam 300®)

Phenelzine (Nardil®)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Pindolol (Visken®)

Pioglitazone (Actos®) –( hypoglycemia usually only when in combination with other diabetic drugs such as sulfonylureas or insulin)

Pioglitazone and Glimepiride (Duetact®) – the glimepiride component of this drug gives it the possibility of causing hypoglycemia alone or in combination with other diabetes medicines. This is more likely to occur when one skips a regular meal or when unusual physical activities occur.

Pioglitazone and Metformin (Actoplus Met®, ActoPlus Met XR®)

Pramlintide (Symlin®)

Pregabalin (Lyrica®)

Probenecid (Benemid®, Probalan®)

Propranolol (Inderal) Quinine (Quinamm®, Quindan®, Quiphile®, Q-vel®, Strema®)

Quinupristin + dalfopristin (Synercid®)

Repaglinide (Prandin®)

Repaglinide and Metformin (PrandiMet®)

Ritodrine (Yutopar®)

Rituximab (Rituxan®)

Rosiglitazone (Avandia®)

Rosiglitazone and Metformin (Avandamet®)

Rotigotine (Neupro®)

Salicylates (Numerous tradenames of aspirin formulations; check the label)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Saxagliptin (Onglyza®)

Saxagliptin + dapagliflozin (Qtern)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Saxagliptin + metformin (Kombiglyze XR®)

Saxagliptin + metformin + dapagliflozin (Qternmet XR)

Selegiline (Eldepryl®)

Semaglutide- (Ozempic, Rybelsus)

Sitagliptin (Januvia®)

Sitagliptin + ertugliflozin (Steglujan)

Sitagliptin and Metformin HCL (Janumet®, Janumet XR)

Sodium ferric gluconate complex (Ferrlecit®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin cartridges®, Norditropin NordiFlex®, Nutropin, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)Sotalol (Betapace®, Betapace AF®, Sorine®)

Streptozocin (Zanosar®)

Sulfadiazine (Microsulfon®)

Tacrolimus P (Prograf®, Protopic®)

Tetracaine (Altacaine®, Tetcaine®, Pontocaine®)

Theophylline (Theo-24®, Theo-Dur®, TheoCap®)

Timolol (Timoptic®, Timoptic-XE®)

Tolazamide (Tolinase®)

Tolbutamide (Orinase®)

Topiramate (Topamax)

Tranylcypromine (Parnate®)Varenicline (Chantix®)

Verapamil (Calan®, Calan SR®, Isoptin SR®, Verelan®)

Drugs that can cause Hyper- or Hypoglycemia

Amphotericin B (Ambisome®, Amphocin®, Fungizone Intravenous® Amphotec®, Abelcet®)

Amphotericin B lipid formulations (Abelcet®, AmBisome®)

Avanafil (Stendra®)

Axitinib (Inlyta®)

Betaxolol Betoptic® eyedrops, (KERLONE® oral)

Bisoprolol + hydrochlorothiazide (Ziac®)

Choline salicylate (Numerous tradenames of aspirin formulations; check the label)

Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®)

Ciprofloxacin (Otiprio®)

Darunavir (Prezista®)

Diazoxide (Proglycem®)

Doxepin (Silenor®)

Elvitegravir + cobicistat + emtricitabine + tenofovir (Stribild®)

Emtricitabine + rilpivirine + tenofovir (Complera®)

Fentanyl (Abstral®, Lazanda®, Subsys®)

Fluoxetine (Prozac®, Sarafem®)

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Ivacaftor (Kalydeco®)

Lanreotide acetate (Somatuline®)

Lenalidomide (Revlimid®)

Lisinopril + Hydrochlorothiazide

Lithium (Eskalith®, Eskalith CR®, Lithobid®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Mecasermin (Increlex ®)

Mecasermin Rinfabate (Iplex ®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Nadolol (Corgard®)

Naproxen + esomeprazole (Vimovo®)

Drugs that can cause Hyper- or Hypoglycemia – Continued

Octreotide (Sandostatin®, Sandostatin LAR® Depot)

Omacetaxine (Synribo®)

Oxcarbazepine (Oxtellar XR®)

Oxycodone + acetaminophen (Xartemis®)

Pancrelipase (Ultresa®, Viokace®)

Paroxetine (Brisdelle®)

Pasireotide (Signifor®)

Pazopanib (Votrient ®)

Pentamidine (Nebupent®, Pentam 300®)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Ponatinib

Rifampin (Rifadin®, Rimactane®)

Ritodrine (Yutopar®)

Rituximab (Rituxan®)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Sitagliptin + simvastatin (Juvisync®)

Sunitinib (Sutent®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin cartridges®, Norditropin NordiFlex®, Nutropin®, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)

Sotalol (Betapace®, Betapace AF®, Sorine®)

Streptozocin (Zanosar®)

Sunitinib (Sutent®)

Pancrelipase (Pancreaze®)

Pasireotide (Signifor®)

Pegloticase (Krystexxa®)

Tacrolimus P (Prograf®, Protopic®)

Testosterone gel (Fortesta®)

Drugs that can cause Hyper- or Hypoglycemia – Continued

Testosterone (Aveed®, Natesto®, Vogelxo®)

Topiramate (Qudexy®)

Vandetanib (Vandetanib®)

Drugs that can MASK* Hypoglycemia

Atenolol (Tenormin®, Tenoretic® containing Atenolol & Chlorthalidone)

Carteolol (Cartrol® oral, Occupress® eyedrops)

Carvedilol (Coreg®, Coreg® Tiltabs®)

Clonidine (Duraclon®, Catapres®, Catapres-TTS-1®, Catapres-TTS-2®, Catapres-TTS-3®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Nadolol (Corgard®)

Nebivolol (Bystolic®)

Pindolol (Visken®)

Propranolol, Propranolol Hydrochloride, (Inderal®, Inderal LA®, Inderide®, Innopran® XL, Intensol®)

Timolol (Timoptic®, Timoptic-XE®)

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* Recent research suggests that this may not occur.

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Because of the continually changing nature of the U.S. prescription and OTC drug marketplace, this list may not reflect the full range of drugs that may impact blood glucose levels. The information contained in this document is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse, or pharmacist before taking any prescription or over-the-counter drugs (including any herbal medicines or supplements) or following any treatment or regimen.

References:

• CenterWatch. FDA Approved Drugs. https://www.centerwatch.com/drug-information/fda-approved-drugs/year/. Accessed February 15, 2016.
• Cherney K. A Complete List of Diabetes Medications. Healthline. http://www.healthline.com/health/diabetes/medications-list#Overview1. Updated, October 21, 2014. Accessed February 15, 2016.
• Clinical Pharmacology. http://www.clinicalpharmacology-ip.com.ezproxy.hsc.usf.edu/default.aspx. Accessed February 15, 2016.
• Dailymed. http://dailymed.nlm.nih.gov/dailymed/. Accessed February 15, 2016.
• Lexicomp. http://online.lexi.com.ezproxy.hsc.usf.edu/lco/action/home. Accessed February 15, 2016.
• Mayo Clinic Staff. Type 1 diabetes: Treatments and drugs. http://www.mayoclinic.org/diseases-conditions/type-1-diabetes/basics/treatment/con-20019573. August 2, 2014. Accessed February 15, 2016.
• Mayo Clinic Staff. Type 2 diabetes: Treatment. Retrieved from http://www.mayoclinic.org/diseases-conditions/type-2-diabetes/in-depth/diabetes-treatment/ART-20051004?pg=2. September 20, 2014. Accessed February 15, 2016.
• Micromedex.http://www.micromedexsolutions.com.ezproxy.hsc.usf.edu/micromedex2/librarian/. Accessed February 15, 2016.
• U.S. Food and Drug Administration. http://www.fda.gov/. Last updated on February 11, 2016. Accessed February 15, 2016.
• What I need to know about diabetes medicines. Retrieved from http://diabetes.niddk.nih.gov/dm/pubs/medicines_ez/. February 19, 2014. Accessed February 15, 2016.
• Ganda, Om P. “Statin-induced diabetes: incidence, mechanisms, and implications.” F1000Research vol. 5 F1000 Faculty Rev-1499. 24 Jun. 2016, doi:10.12688/f1000research.8629.1
• Vue, Mays H., and Stephen M. Setter. “Drug-Induced Glucose Alterations Part 1: Drug-Induced Hypoglycemia.” Diabetes Spectrum, American Diabetes Association, 1 Aug. 2011, spectrum.diabetesjournals.org/content/24/3/171.
• “Sign in with an OpenAthens Account.” OpenAthens / Sign In, www-Micromedex solutions-com.eu1.proxy.openathens.net/micromedex2/librarian/PFDefaultActionId/evidencexpert.DoIntegratedSearch?navitem=headerLogout#.