Which Drugs Affect Blood Glucose Levels? - 443 OTC & Prescription Meds (2022)

What drugs affect glucose levels? Many can, including steroids, anxiety and depression medications, statins, beta-blockers, some acne & asthma medications.

Knowing which drugs affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way.

443 Drugs that can Affect Blood Glucose Levels is also available as a downloadable PDF.

Last Revised: 04/5/2020

Table of Contents:

Drugs that May Cause Hyperglycemia

Drugs that May Cause Hypoglycemia

Drugs that May Cause Hyper- or Hypoglycemia

Drugs that Mask Hypoglycemia

DiabetesinControl 2020©

Drugs That May Cause Hyperglycemia (High Blood Sugar)

Abacavir (Ziagen®)

Abacavir + lamivudine, zidovudine (Trizivir®)

Abacavir + dolutegravir + lamivudine (Triumeq®)

Abiraterone (Zytiga®)

Acetazolamide (Diamox®)

Acitretin (Soriatane®)

Albuterol (Ventolin®, Proventil®)

Albuterol + ipratropium (Combivent®)

Alectinib (Alecensa®)

Aliskiren + amlodipine + hydrochlorothiazide (Amturnide®)

Aliskiren + amlodipine (Tekamlo®)Ammonium chloride

Amphotericin B (Amphocin®, Fungizone®)

Amphotericin B lipid formulations IV (Abelcet®)

Amprenavir (Agenerase®)

Anidulafungin (Eraxis®)

Aripiprazole (Abilify®)

Arsenic trioxide (Trisenox®)

Asenapine (Saphris)

Asparaginase (Elspar®, Erwinaze®)

Atazanavir (Reyataz ®)

Atazanavir + cobistat (Evotaz®)

Atenolol + chlorthalidone (Tenoretic®)

Atorvastatin (Lipitor®)

Atovaquone (Mepron®)

Baclofen (Lioresal®)

Belatacept (Nulojix®)Benazepril + hydrochlorothiazide (Lotension®)

Betamethasone topical (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Betamethasone +clotrimazole (Lotrisone® topical)

Betaxolol Betoptic® eyedrops, (Kerlone® oral)

Bexarotene (Targretin®)

Bicalutamide (Casodex®)

Bisoprolol + hydrochlorothiazide (Ziac®)

Brentuximab vedotin (Adcetris®)

Budesonide (Uceris®)

Bumetanide (Bumex®)

Caffeine (Caffeine in moderation may be beneficial in diabetes, but in large amounts can raise blood sugar.)

Calcipotriene + betamethasone (Enstillar®)

Candesartan + hydrochlorothiazide (Atacand HCT®)Captopril + hydrochlorothiazide (Capozide®)

Carfilzomib (Kyprolis®)

Cariprazine (Vraylar)

Carteolol (Cartrol® oral, Occupress® eyedrops)

Carvedilol (Coreg®)

Caspofungin (Cancidas)

Ceftaroline (Teflaro®)

Ceftozolane + tazobactam (Zerbaxa)

Ceritinib (Zykadia)

Chlorothiazide (Diuril®)

Chlorthalidone (Chlorthalidone Tablets®, Clorpres®, Tenoretic®, Thalitone®)

Choline salicylate (Numerous tradenames of aspirin formulations; check the label)

Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®)

Ciprofloxacin (Cipro)

Clobetasol (Clobevate®, Cormax®, Cormax® Scalp Application, Embeline® E, Olux®, Temovate®, Temovate® E, Temovate® Scalp Application)

Clozapine (Clozaril®, FazaClo®)

Conjugated estrogens (Estrace®, Estring®, Femring®, Premarin®, Vagifem®, Cenestin®, Enjuvia®, Estrace®, Femtrace®, Gynodiol®, Menest®, Ogen®)

Conjugated estrogens + bazedoxifene (Duavee®)

Conjugated estrogens + medroxyprogesterone (Premphase®, Prempro®)

Corticosteroids (Numerous tradenames; check the label)

Corticotropin

Cortisone (Numerous tradenames; check the label)

Crizotinib (Xalkori)

Cyclosporine (Sandimmune®, Neoral®, Gengraf®)

Dabrafenib (Tafiniar®)

Daclizumab (Zenapax®)

Darunavir (Prezista)

Darunavir + cobistat (Prezcobix®)

Decitabine (Dacogen®)

Desonide (DesOwen®, Tridesilon®)

Desoximetasone (Topicort®)

Dexamethasone (Adrenocot®, Dalalone®, Decadron®, Decaject®, Dekasol®, Dexacort®, Dexasone®, Dexim®, Dexone®, Hexadrol®, Medidex®, Primethasone®, Solurex®, Dexamethasone Intensol®)

Dextromethorphan + promethazine (Phenergan® with Dextromethorphan, Phen- TussDM®)

Diazoxide (Proglycem®)

Dinutuximab (Unituxin®)

Dolutegravir (Tivicay®)

Enalapril + hydrochlorothiazide (Vaseretic®)Encainide (Enkaid®)

Ephedrine and Guaifenesin (Primatene ® tablets, otc – this medication includes ephedrine and guaifenesin. Guaifenesin is not responsible for hyperglycemia )

Epinephrine (EpiPen ®, EpiPen® Jr, Primatene® Mist, otc)

Esterified estrogens, estrone, estropipate

Esterified estrogens + methyltestosterone (Estratest®)

Estradiol, ethinyl estradiol (Alora®, Climara®, Congest®, Delestrogen®, Depo-Estradiol®, Depogen®, Estinyl®, Estrace®, Estraderm®, Estragyn 5®, Estragyn LA 5®, Estrasorb®, EstroGel®, Estro-L.A.®, Gynodiol®, Kestrone-

5®, Neo-Estrone®, Menest®, Menostar®, Ogen .625®, Ogen®, Ortho-Est®, Premarin®, Valergen®, Vivelle®, Vivelle-Dot®)

Estradiol + norethindrone (Activella®)

(Video) Pharmacology - DRUGS FOR DIABETES (MADE EASY)

Estradiol + norgestimate (Prefest®)

Estramustine (Emcyt®)

Ethacrynic acid (Edecrin®, Sodium Edecrin®)

Etravirine (Intelence)

Everolimus (Afinitor®, Zortress®)

Everolimus (Zortress®)

Ezetimibe, Atorvastatin (Liptruzet®)

Fidaxomicin (Dificid®)

Fluconazole (Diflucan)

Fluticasone (Arnuity Ellipta®)

Fluticasone + vilanterol (Breo Elipta®)

Fluoxetine (Prozac®, Sarafem®)

Flurandrenolide (Cordran®, Cordran® SP, Cordran® Tape)

Fluvastatin (Lescol, Lescol XR)

Formoterol (Foradil® Aerolizer® Inhaler)

Fosamprenavir (Lexiva ®)

Fosinopril + hydrochlorothiazide (Monopril HCT®)

Furosemide (Lasix®)

Gabapentin (Gralise®, Horizant®)

Gemtuzumab ozogamicin (Mylotarg®)

Glucosamine (Possible increase in insulin resistance; more likely with intravenous use)

Glycopyrrolate (Cuvposa®)

Hydrochlorothiazide (Aldactazide®, Aldoril®, Capozide®, Dyazide®, HydroDIURIL®, Inderide®, Lopressor® HCT, Maxzide®, Microzide®, Moduretic®, Timolide®, Vaseretic®)

Hydrochlorothiazide + irbesartan (Avalide®)

Hydrochlorothiazide + lisinopril (Prinzide®, Zestoretic®)

Hydrochlorothiazide + losartan (Hyzaar®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Hydrochlorothiazide + moexipril (Uniretic®)

Hydrochlorothiazide + quinapril (Accuretic®, Quinaretic®)

Hydrochlorothiazide + telmisartan (Micardis HCT®)

Hydrochlorothiazide + valsartan (Diovan HCT®)

Hydrocortisone (Numerous trade names of topical hydrocortisone formulations; check the label)

Iloperidone (Fanapt)

Indacaterol (Arcapta®)

Indapamide (Lozol®)

Indinavir (Crixivan®)

Interferon alfa-2a (Roferon-A®)

Interferon alfa-2b (Intron-A®)

Interferon alfa-2b + ribavirin (Rebetron®)

Interferon alfa-n1 (Alferon-N®)

Irinotecan (Camptosar®)

Isavuconazonium sulfate (Cresemba)

Isoniazid (Laniazid®, Nydrazid®)

Isotretinoin (Accutane®)

Itraconazole (Sporanox, Sporanox PuslePak, Tolsura)

Ketoconazole (Nizoral)

Liothyronine (Cytomel®)

Lamivudine (Epivir®, Epivir-HBV®)

Levalbuterol (Xoponex®, Xopenex HFA®)

Levonorgestrel (Plan B®, Norplant System®)

Levothyroxine (Synthroid®, Levoxyl®)

Lisinopril + Hydrochlorothiazide

Lopinavir + ritonavir (Kaletra®)

Lovastatin (Altoprev, Mevacor)

Lucinactant (Surfaxin®)

Lurasidone (Latuda®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Medroxyprogesterone (Provera®, Depo-Provera®)

Megestrol (Megace®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Methylprednisolone (A-methaPred®, ADD-Vantage®, Depo-Medrol®, Medrol®,
Medrol® Dosepak, Meprolone® Unipak, Solu-Medrol®)

Metolazone (Zaroxolyn®, Mykrox®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Micafungin (Mycamine)

Modafinil (Provigil®)

Momentasone furoate + formoterol fumarate dihydrate (Dulera®)

Moxifloxacin (Avelox®, Avelox® I.V.)

Mycophenolate (CellCept®)

Nadolol (Corgard®)

Nelfinavir (Viracept®)

Netupitant + palonosetron (Akynzo®)

Niacin, niacinamide (Niacor®, Niaspan®, Nicolar®, Nicotinex®, Slo-Niacin®)

Nilotinib (Tasigna®)

Nilutamide (Nilandron®)

Nitric oxide (INOmax®)

Nivolumab (Opdivo®)

Norethindrone (Aygestin®, Nor-QD®, Micronor®)

Norgestrel (Orvette®)

Nystatin (Mycostatin®, Nystat-Rx®, Nystop®, Pedi-Dri®)

Nystatin + triamcinolone (Dermacomb®, Myco II®, Mycobiotic II®, Mycogen II®,
Mycolog II®, Myco-Triacet II®, Mykacet®, Mykacet II®, Mytrex®, Tristatin II®)

Octreotide (Sandostatin®, Sandostatin LAR®)

Olanzapine (Zyprexa®)

Olaparib (Lynparza®)

Olmesartan + amlodipine + hydrochlorothiazide (Tribenzor®)

Oxybutynin (Anturol®)

Oxycodone (Oxecta®)

Paliperidone (Invega, Invega Sustenna, Invega Trinza)

Panobinostat (Farydak®)

Pantoprazole (Protonix®, Protonix® I.V.)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Pegaspargase (Oncaspar®)

Peginterferon alfa-2b (PEG-Intron®, Sylatron®)

(Video) Farxiga a Prescription Medication Used to Control Blood Sugar Levels - Overview

Pembrolizumab (Keytrenda®)

Pentamidine (Pentam 300®)

Peramivir (Rapivab®)

Perindopril + amlodipine (Prestalia®)

Phenylephrine* (Sudafed PE®, and others)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Pitavastatin (Livalo, Zypitamag)

Pomalidomide (Pomalyst®)

Posaconazole (Noxafil)

Pravastatin (Pravachol)

Prednisolone (AK-Pred®, Blephamide®, Blephamide®, Liquifilm®, Econopred® Plus, Inflamase® Forte, Inflamase® Mild, Poly-Pred® Liquifilm®, Pred Forte®, Pred Mild®, Pred-G®, Pred-G® Liquifilm®, Delta Cortef®, Pediapred®, Prelone®)

Prednisone (Prednisone Intensol®, Sterapred®, Sterapred® DS, Rayos DR®)

Progesterone (Prometrium®)

Pseudoephedrine* (Claritin D®, Sudafed®, and others)

Quetiapine (Seroquel®)

Risperidone (Risperdal®, Risperdal® M-TAB®)

* many other OTC and prescription medications contain pseudoephedrine and phenylephrine.

Ritodrine (Yutopar®)

Ritonavir (Norvir®)

Rituximab (Rituxan®)

Rosuvastatin (Crestor)

Salmeterol (Serevent®, Serevent® Diskus®)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Saquinavir (Invirase®)

Simvastatin (Zocor)

Simvastatin + ezetimibe (Vytorin)

Sodium oxybate (Xyrem®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin artridges®, Norditropin NordiFlex®, Nutropin®, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Sonidegib (Odomzo®)

Sotalol (Betapace®, Betapace AF®, Sorine®)

Stavudine (Zerit)

Streptozocin (Zanosar®)

Tacrolimus (Prograf®, Protopic®)

Temsirolimus (Torisel®)

Tesamorelin (Egrifta®)

Thyroid (Armour Thyroid®, Naturethroid®)

Tiotropium + Olodaterol (Stiolto Respimat®)

Tipranavir (Aptivus®)

Tolvaptan (Samsca®)

Torsemide (Demadex®, Demadex Oral®)

Trametinib (Mekinist®)

Triamcinolone (Aristocort®, Aristospan®, Asthmacort®, Flutex®, Kenalog®, Tac®, Triacet®)

Umeclidium + vilanterol (Anoro Ellipta®)

Ursodeoxycholic acid, ursodiol (Actigall®, Urso®)

Valproic acid, divalproex sodium (Depacon®, Depakene®, Depakene® Syrup, Depakote®, Depakote® ER, Depakote® Sprinkle)

Vitamin C (Ascorbic acid, Ascorbate)

Vitamin E (Tocopherol, Tocotrienol)

Voriconazole (Vfend)

Zidovudine (Retrovir)

Ziprasidone (Geodone®)

Zolpidem (Intermezzo®)

Drugs That May Cause Hypoglycemia (Low Blood Sugar)

Acebutolol (Sectral®)

Acetohexamide (Dymelor®)

Albiglutide (Tanzeum®)

Alcohol

Albiglutide (Tanzeum)

Aloe – Oral Herbal Supplement, especially if taken with other agents such as glyburide, glipizide, nateglinide, repaglinide, glimepiride, or insulin.

Alogliptin (Nesina®)

Alogliptin/pioglitazone (Oseni®)

Alogliptin/metformin (Kazano®)

Amphotericin B (Ambisome®, Amphocin®, Fungizone Intravenous® Amphotec®, Abelcet®)

Amphotericin B lipid formulations (Abelcet®, AmBisome®)

Aripiprazole (Aristada®)Asian Ginseng (Ginseng; Panax ginseng)

Aspirin (Numerous tradenames; check the label)

Aspirin + dipyridamole (Aggrenox®)

Atenolol (Tenormin®, Tenoretic® containing atenolol & chlorthalidone)

Benazepril (Lotensin)

Betaxolol (Betoptic®, Betoptic S® eyedrops, Kerlone® oral)

Bisoprolol (Zebeta®)

Bisoprolol + hydrochlorothiazide (Ziac®)

Brexpiprazole (Rexulti®)

Bromocriptine (Cycloset®)

Canagliflozin (Invokana®)

Canagliflozin + metformin (Invokamet®)

Chloramphenicol (Chloromycetin®)

Chlorpropamide (Diabinese®)

Choline salicylate (Acuprin 81®, Amigesic®, Anacin Caplets®, Anacin Maximum Strength®, Anacin Tablets®, Anaflex 750® Arthritis Pain, Ascriptin® Arthritis Pain)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Choline salicylate + magnesium salicylate C (MT®, Tricosal®, Trilisate®)

Chloramphenicol (Chloromycetin, Econochlor, Ocu-Chlor)Chloroquine (Aralen)

Chromium (Various tradenames; check the label)

Ciprofloxacin (Cipro)

Clarithromycin B (Biaxin® Filmtab®, Biaxin® Granules, Biaxin® XL, Filmtab,
Biaxin® XL Pac, Prevpac®)

Clofibrate (Atromid-S)

Colesevelam (Welchol)

Dalbavancin (Dalvance®)

Dapagliflozin (Farxiga®)

Dapagliflozin + Metformin (Xigduo XR®)

Diazoxide (Proglycem®)

Dicumarol (Coumadin®, Miradon®)

Diltiazem (Cardizem®, Tiazac®)

(Video) How to bring down high blood sugar levels (hyperglycemia)

Disopyramide (Norpace®, Norpace® CR)

Dorzolamide + timolol (Cosopt®)

Doxepin (Silenor®)

Dulaglutide (Trulicity®)

Empagliflozin (Jardiance®)

Empagliflozin/linagliptin (Glyxambi®)

Empagliflozin + metformin (Synjardy®)

Enalapril (Vasotec)

Ertugliflozin ( Steglatro)

Ertugliflozin + metformin (Segluromet)

Ertugliflozin + metformin + linagliptin (Trijardy)

Esmolol (Brevibloc)

Exenatide (Byetta®, Bydureon®)

Fluoxetine (Prozac®, Sarafem®)

Fosphenytoin (Cerebyx®, Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Mesantoin®, Peganone®, Phenytek®)

Gatifloxacin (Gatiflo, Tequin, Zymar)

Glimepiride (Amaryl®)

Glimepiride and Rosiglitazone (Avandaryl®)

Glimepiride + pioglitazone (Duetact)

Glipizide (Glucotrol®, Glucotrol XL®)

Glipizide and Metformin (Metaglip®)

Glucagon (GlucaGen®)

Glyburide (Diabeta®, Glynase®, Micronase®, Glycron®)

Glyburide + metformin (Glucovance®)

Horse chestnut (Aesculus hippocastanum)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Hydroxychloroquine (Plaquenil)

Indomethacin (Indocin)

Insulin (Lantus®, Levemir®, NPH®, Humulin®, Novolin®, Apidra®, Novolog®, Humalog®, Tresiba®, Afrezza®- inhaled, Abasaglar®, Ryzodeg®, Xultophy®- not FDA approved, Toujeo®, Locemia®- not FDA approved, V-go®)

Interferon beta-1b (Betaseron®)

Isavuconazonium (Cresemba®)

ITCA 650®- Not FDA approved

Lenvatinib (Lenvima®)

Levobunolol (AKBeta, Betagan, Vistagan)

Levofloxacin (Levaquin®, Levaquin® in Dextrose Injection Premix, Quixin®)

Linagliptin (Tradjenta®)

Linagliptin + empagliflozin (Glyxambi)

Linagliptin + metformin (Jentadueto®, Jentadueto XR)

Liraglutide (Victoza®, Saxenda®)

Liraglutide + insulin degludec (Xultophy)

Lisinopril (Prinivil, Zestril, Qbrelis)

Lithium (Eskalith, Lithobid)

Lixisenatide (Lyxumia®)- currently approved in Europe

Lixisenatide/ insulin Glargine (Soliqua®)-

Lorcaserin (Belviq®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, Riomet®)

Metipranolol (Optipranolol)

metreleptin (Myalept®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Metreleptin (Myalept®)

Mifepristone (Korlym®)

Morphine (Kadian®, MS Contin®, MSIR®, Roxanol®)

Moxifloxacin (Avelox)

Nadolol (Corgard®)

Nateglinide (Starlix®)

Nebivolol (Bystolic)

Nifedipine (Adalat CC®, Procardia®, Afeditab ® CR)

Nivolumab (Opdivo®)

Norfloxacin (Noroxin)

Octreotide (Sandostatin®, Sandostatin LAR® Depot)

Ofloxacin (Oxuflox)

Oritavancin (Orbactiv®)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Paliperidone (Invega®)

Penicillamine (Cuprimine®, Depen®)

Pentamidine (Nebupent®, Pentam 300®)

Phenelzine (Nardil®)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Pindolol (Visken®)

Pioglitazone (Actos®) –( hypoglycemia usually only when in combination with other diabetic drugs such as sulfonylureas or insulin)

Pioglitazone and Glimepiride (Duetact®) – the glimepiride component of this drug gives it the possibility of causing hypoglycemia alone or in combination with other diabetes medicines. This is more likely to occur when one skips a regular meal or when unusual physical activities occur.

Pioglitazone and Metformin (Actoplus Met®, ActoPlus Met XR®)

Pramlintide (Symlin®)

Pregabalin (Lyrica®)

Probenecid (Benemid®, Probalan®)

Propranolol (Inderal) Quinine (Quinamm®, Quindan®, Quiphile®, Q-vel®, Strema®)

Quinupristin + dalfopristin (Synercid®)

Repaglinide (Prandin®)

Repaglinide and Metformin (PrandiMet®)

Ritodrine (Yutopar®)

Rituximab (Rituxan®)

Rosiglitazone (Avandia®)

Rosiglitazone and Metformin (Avandamet®)

Rotigotine (Neupro®)

Salicylates (Numerous tradenames of aspirin formulations; check the label)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Saxagliptin (Onglyza®)

Saxagliptin + dapagliflozin (Qtern)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Saxagliptin + metformin (Kombiglyze XR®)

Saxagliptin + metformin + dapagliflozin (Qternmet XR)

(Video) The Foods That Help Lower Blood Sugar Levels

Selegiline (Eldepryl®)

Semaglutide- (Ozempic, Rybelsus)

Sitagliptin (Januvia®)

Sitagliptin + ertugliflozin (Steglujan)

Sitagliptin and Metformin HCL (Janumet®, Janumet XR)

Sodium ferric gluconate complex (Ferrlecit®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin cartridges®, Norditropin NordiFlex®, Nutropin, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)Sotalol (Betapace®, Betapace AF®, Sorine®)

Streptozocin (Zanosar®)

Sulfadiazine (Microsulfon®)

Tacrolimus P (Prograf®, Protopic®)

Tetracaine (Altacaine®, Tetcaine®, Pontocaine®)

Theophylline (Theo-24®, Theo-Dur®, TheoCap®)

Timolol (Timoptic®, Timoptic-XE®)

Tolazamide (Tolinase®)

Tolbutamide (Orinase®)

Topiramate (Topamax)

Tranylcypromine (Parnate®)Varenicline (Chantix®)

Verapamil (Calan®, Calan SR®, Isoptin SR®, Verelan®)

Drugs that can cause Hyper- or Hypoglycemia

Amphotericin B (Ambisome®, Amphocin®, Fungizone Intravenous® Amphotec®, Abelcet®)

Amphotericin B lipid formulations (Abelcet®, AmBisome®)

Avanafil (Stendra®)

Axitinib (Inlyta®)

Betaxolol Betoptic® eyedrops, (KERLONE® oral)

Bisoprolol + hydrochlorothiazide (Ziac®)

Choline salicylate (Numerous tradenames of aspirin formulations; check the label)

Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®)

Ciprofloxacin (Otiprio®)

Darunavir (Prezista®)

Diazoxide (Proglycem®)

Doxepin (Silenor®)

Elvitegravir + cobicistat + emtricitabine + tenofovir (Stribild®)

Emtricitabine + rilpivirine + tenofovir (Complera®)

Fentanyl (Abstral®, Lazanda®, Subsys®)

Fluoxetine (Prozac®, Sarafem®)

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Ivacaftor (Kalydeco®)

Lanreotide acetate (Somatuline®)

Lenalidomide (Revlimid®)

Lisinopril + Hydrochlorothiazide

Lithium (Eskalith®, Eskalith CR®, Lithobid®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Mecasermin (Increlex ®)

Mecasermin Rinfabate (Iplex ®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Nadolol (Corgard®)

Naproxen + esomeprazole (Vimovo®)

Drugs that can cause Hyper- or Hypoglycemia – Continued

Octreotide (Sandostatin®, Sandostatin LAR® Depot)

Omacetaxine (Synribo®)

Oxcarbazepine (Oxtellar XR®)

Oxycodone + acetaminophen (Xartemis®)

Pancrelipase (Ultresa®, Viokace®)

Paroxetine (Brisdelle®)

Pasireotide (Signifor®)

Pazopanib (Votrient ®)

Pentamidine (Nebupent®, Pentam 300®)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Ponatinib

Rifampin (Rifadin®, Rimactane®)

Ritodrine (Yutopar®)

Rituximab (Rituxan®)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Sitagliptin + simvastatin (Juvisync®)

Sunitinib (Sutent®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin cartridges®, Norditropin NordiFlex®, Nutropin®, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)

Sotalol (Betapace®, Betapace AF®, Sorine®)

Streptozocin (Zanosar®)

Sunitinib (Sutent®)

Pancrelipase (Pancreaze®)

Pasireotide (Signifor®)

Pegloticase (Krystexxa®)

Tacrolimus P (Prograf®, Protopic®)

Testosterone gel (Fortesta®)

Drugs that can cause Hyper- or Hypoglycemia – Continued

Testosterone (Aveed®, Natesto®, Vogelxo®)

Topiramate (Qudexy®)

Vandetanib (Vandetanib®)

Drugs that can MASK* Hypoglycemia

Atenolol (Tenormin®, Tenoretic® containing Atenolol & Chlorthalidone)

Carteolol (Cartrol® oral, Occupress® eyedrops)

Carvedilol (Coreg®, Coreg® Tiltabs®)

Clonidine (Duraclon®, Catapres®, Catapres-TTS-1®, Catapres-TTS-2®, Catapres-TTS-3®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Nadolol (Corgard®)

Nebivolol (Bystolic®)

Pindolol (Visken®)

Propranolol, Propranolol Hydrochloride, (Inderal®, Inderal LA®, Inderide®, Innopran® XL, Intensol®)

Timolol (Timoptic®, Timoptic-XE®)

_________________

* Recent research suggests that this may not occur.

__________________

Because of the continually changing nature of the U.S. prescription and OTC drug marketplace, this list may not reflect the full range of drugs that may impact blood glucose levels. The information contained in this document is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse, or pharmacist before taking any prescription or over-the-counter drugs (including any herbal medicines or supplements) or following any treatment or regimen.

References:

(Video) I Wore a Blood Glucose Monitor (CGM) for a Month. Here's What Happened

FAQs

What medications can affect blood sugar levels? ›

Antidepressants (Zyprexa, risperdal, Clozaril, Seroquel, Abilify, Geodon, lithium) Beta-2 stimulators (Proventil, Alupent, Serevent, Foradil, Brethine, Theo-Dur) Caffeine. Corticosteroids (Prednisone, Decadron, DepoMedrol)

What blood pressure meds cause high blood sugar? ›

Hydrochlorothiazide (HCTZ) and chlorthalidone are diuretics used to lower blood pressure but may increase your risk for high blood sugar and diabetes.

Which 3 medications are used to regulate blood glucose levels treat diabetes? ›

What Are the Best Drugs to Treat Diabetes?
  • Insulin (long- and rapid-acting)
  • Metformin (biguanide class)
  • Glipizide (sulfonylurea class)
26 Jul 2020

What can I take instead of metformin? ›

Other alternatives to metformin
  • Avandia (rosiglitazone)
  • Nesina (alogliptin)
  • Tanzeum (albiglutide)
  • Jardiance (empagliflozin)
  • Invokana (canagliflozin)
  • Farxiga (dapagliflozin)
21 Mar 2022

What vitamins and supplements raise blood sugar? ›

Vitamin B3 or Niacin, taken to reduce bad cholesterol, increases insulin resistance and raises blood sugar levels.

What medications can trigger diabetes? ›

Which drugs can induce diabetes?
  • Corticosteroids.
  • Thiazide diuretics.
  • Beta-blockers.
  • Antipsychotics.
  • Statins.
15 Jan 2019

What is the new pill for diabetes? ›

Tirzepatide is the first drug in a new class of diabetes medications. It is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. GLP-1 and GIP are gut hormones called incretins, and the intestines release them when we eat.

What is the best high blood pressure medication for diabetes? ›

The most commonly used medications to lower blood pressure in people with diabetes are ACE inhibitors (like lisinopril and enalapril) and ARBs (like losartan and candesartan). These medications work on the kidney to lower blood pressure.

Can blood pressure medicine mess with your blood sugar? ›

Beta-Blockers for Conditions Such as Arrhythmia and Anxiety. This large class of drugs is used to lower blood pressure and treat a variety of other conditions, including irregular heartbeat and anxiety, but they can also raise your blood sugar levels.

What is the normal blood sugar level for a 70 year old? ›

Normal ranges of blood sugar levels are between 70 and 130 mg/dL before eating meals. The American Diabetes Association recommends seniors have blood glucose levels of less than 180 mg/dL two hours after eating. Not every senior has the same care needs, which means they don't all need the same type of at-home care.

What is the best medication to lower A1C? ›

  • Alpha-glucosidase inhibitors. Acarbose (Precose) and miglitol (Glyset) are alpha-glucosidase inhibitors. ...
  • Biguanides. Metformin (Glucophage) is a biguanide. ...
  • Bile Acid Sequestrants (BASs) ...
  • Dopamine-2 Agonists. ...
  • DPP-4 Inhibitors. ...
  • Meglitinides. ...
  • SGLT2 Inhibitors. ...
  • Sulfonylureas.

What is the most prescribed drug for type 2 diabetes? ›

Metformin (Fortamet, Glumetza, others) is generally the first medication prescribed for type 2 diabetes. It works primarily by lowering glucose production in the liver and improving your body's sensitivity to insulin so that your body uses insulin more effectively.

Is there a better pill than metformin? ›

There are six other major classes of blood-sugar lowering drugs used in Type 2 diabetes. Of these, the SGLT2 inhibitors (short for sodium-glucose co-transporter) are emerging as the next best drug after metformin.

Does metformin harm your kidneys? ›

Metformin doesn't cause kidney damage. The kidneys process and clear the medication out of your system through your urine. If your kidneys don't function properly, there's concern that metformin can build up in your system and cause a condition called lactic acidosis.

How long can you stay on metformin? ›

As your cells absorb less sugar, it builds up in the blood. Metformin reverses that process. Your doctor will probably start you off on a low dose and work you up to the maximum dose over a period of 4 weeks, and that's where you will stay (if you can tolerate it) for the rest of your life.

What vitamins should you not take with diabetes? ›

Supplements may cause unwelcome—or dangerous—side effects, especially if they interact with your medications.
...
John's wort, or niacin.
  • Chromium. A chromium deficiency may lead to high blood sugar levels. ...
  • Vitamin E & St. John's Wort. ...
  • Niacin.

Do vitamin D supplements raise blood sugar? ›

Intake of vitamin D supplements led to a marginally significant decrease in fasting blood glucose [FBS: −12 (4) in the intervention group compared to − 3 (2) in the control group; P = 0.055].

What Vitamin stabilizes blood sugar? ›

Vitamin B6 helps control blood sugar levels in people with diabetes, and since there are similarities in the way the body regulates high and low blood sugar levels, it might be helpful for hypoglycemia as well.

Does Tylenol raise your blood sugar? ›

Tylenol does not have an effect on blood glucose levels.

Does ibuprofen raise blood sugar? ›

You may take a low dose of aspirin or a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen to relieve the occasional headache or muscle pain. A regular dose is unlikely to affect your blood sugar levels, but a higher-than-usual dose may lower your blood sugar level.

Does Claritin raise blood sugar? ›

Thankfully, antihistamines, including the popular allergy medicine Claritin, do not raise blood sugar. However, some products, such as Benadryl, may cause drowsiness, and interfere with your daily activities, including your diabetes care.

Can vitamins raise blood sugar? ›

A number of over-the-counter (OTC) and prescription drugs — even some vitamins and supplements — can raise blood sugar.

What can cause a false high blood sugar reading? ›

However, various factors such as application errors, extreme environmental conditions, extreme hematocrit values, or medication interferences may potentially falsify blood glucose readings. Incorrect blood glucose readings may lead to treatment errors, for example, incorrect insulin dosing.

What is the new pill for diabetes? ›

Tirzepatide is the first drug in a new class of diabetes medications. It is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. GLP-1 and GIP are gut hormones called incretins, and the intestines release them when we eat.

Does caffeine raise blood sugar? ›

For most young, healthy adults, caffeine doesn't appear to noticeably affect blood sugar (glucose) levels, and having up to 400 milligrams a day appears to be safe.

Can drinking a lot of water lower your blood sugar? ›

Drinking water regularly may rehydrate the blood, lower blood sugar levels, and reduce diabetes risk ( 20 , 21 ). Keep in mind that water and other zero-calorie drinks are best. Avoid sugar-sweetened options, as these can raise blood glucose, drive weight gain, and increase diabetes risk ( 22 , 23 ).

Can lack of sleep cause high blood sugar? ›

A: Yes. Multiple studies have shown that repeated awakenings during the night, insufficient sleep, excessive sleep, and irregular sleep all promote glucose intolerance. Furthermore, if a person has prediabetes or diabetes, poor sleep will worsen the condition.

What pain reliever should diabetics use? ›

NSAIDS,aspirin,ibuprofen,naproxen etc can be taken by diabetics safely. Although, one should keep in mind that painkillers if used excessively can have side effects such as stomach ulcer, kidney damage.

Does Benadryl lower blood sugar? ›

Antihistamines—they tend to not affect blood sugar; however, antihistamines do tend to make you drowsy. Therefore, it is important to understand that long periods of drowsiness can also be associated with hypoglycemia and hyperglycemia. Drowsiness may make you less able to accurately monitor blood sugar.

What is the best medicine to lower a1c? ›

  • Alpha-glucosidase inhibitors. Acarbose (Precose) and miglitol (Glyset) are alpha-glucosidase inhibitors. ...
  • Biguanides. Metformin (Glucophage) is a biguanide. ...
  • Bile Acid Sequestrants (BASs) ...
  • Dopamine-2 Agonists. ...
  • DPP-4 Inhibitors. ...
  • Meglitinides. ...
  • SGLT2 Inhibitors. ...
  • Sulfonylureas.

Does omeprazole raise blood sugar? ›

Omeprazole therapy significantly improved blood glucose levels, as evidenced by the improvement in HbA1c levels. These findings are consistent with the findings of prior international studies, which used various combinations of anti-glycaemic agents in conjunction with PPIs and assessed the FBS and HbA1c levels.

What vitamins should you not take with diabetes? ›

Supplements may cause unwelcome—or dangerous—side effects, especially if they interact with your medications.
...
John's wort, or niacin.
  • Chromium. A chromium deficiency may lead to high blood sugar levels. ...
  • Vitamin E & St. John's Wort. ...
  • Niacin.

Does vitamin D cause blood sugar rise? ›

Vitamin D supplementation may help lower average blood sugar levels in people with type 2 diabetes; and is especially effective in people who also have a vitamin D deficiency, and are non-obese and deficient. Supplementation for more than 12 weeks at ≥ 1000 IU/day may be most beneficial.

Can low vitamin D cause high blood sugar? ›

Vitamin D deficiency has been linked to prediabetes, which is a blood glucose, or sugar, level that is too high but not high enough to be considered diabetes. It is unclear, however, if bringing low vitamin D blood levels to normal through supplementation will affect progression to diabetes.

Videos

1. The Dexcom G6 Can Read Your Blood Sugar Without Any Blood | CNBC
(CNBC)
2. What To Avoid When Taking Metformin | Drug Interactions | Pharmacology
(JJ Medicine)
3. Unboxing and Setup: LEVELS Continuous Glucose Monitor (CGM)
(Connect The Watts)
4. Reversing Type 2 diabetes starts with ignoring the guidelines | Sarah Hallberg | TEDxPurdueU
(TEDx Talks)
5. Healthy Living for Life – Knowing What Is in Your Medicine Cabinet (Full Version)
(Mountain-Pacific Quality Health)
6. 10 Best Diabetes Exercises to Lower Blood Sugar Exercise - Diabetes Workout
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